The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Although nearly 10% of DLBCL cases are reported to be EBV positive and are mainly seen in elderly people [28], EBV was not detected in any of our DLBCL cases. Six of the cases exhibited tongue base masses with smooth surface membranes. The aetiological factors for lymphoma of the oral region other than EBV and HIV are little known. Lee JT, Paquette R, Sercarz JA, Wang MB. https://doi.org/10.1111/aos.12189. A man in his fourth decade was admitted with pharyngeal foreign body sensation for two months. https://www.linkedin.com/showcase/4000114/. Aggregates of lymphoid tissue are all over the oral mucosa, but they are often prominent in the soft palate, uvula, and pharynx. Final pathology was determined on postoperative day (POD) 2 to be benign follicular/intrafollicular lymphoid hyperplasia characterized by polyclonal lymphoid proliferation with an inflammatory background. J Postgrad Med. This distribution is similar to that in previous reports [18,19,20,21,22] .The most common location was the base of the tongue. Tumours in this site are predominantly DLBCL subtypes in histology. Metastasis of the regional neck lymph nodes was noted in one case at the time of diagnoses. The .gov means its official. https://doi.org/10.1016/S0344-0338(11)80514-5. Bookshelf Except in one case of four, all of our patients were alive through follow-up. There was no cervical adenopathy, and CT of the thorax and abdomen was negative. Acta Oncol. National Library of Medicine Eur Arch Otorhinolaryngol. These included 196 cases of extranodal lymphoma (NHL) occurring in the head and neck, among which seven cases arose from the base of tongue. sharing sensitive information, make sure youre on a federal Mantle cell lymphoma: 2012 update on diagnosis, risk-stratification, and clinical management. Disclaimer. 2000;46:2112. A lymphoid follicle under microscope is shown in Figure 2. B. C. Jham, N. O. Binmadi, M. A. Scheper et al., Follicular lymphoid hyperplasia of the palate: case report and literature review, Journal of Cranio-Maxillofacial Surgery, vol. Shimada K. Molecular pathogenesis and treatment strategy in diffuse large B-cell lymphoma. Baran M, Canoz O, Altuntas H, Sivgin S, Cetin M, Yay A, Ketenci S. Immunohistochemical investigation of P16, P53 and Ki-67's prognostic values in diffuse large B-cell lymphomas. https://doi.org/10.1038/modpathol.2011.45. showed that loss of P16 expression has no effect on life expectancy [33], but high P16 levels may inhibit tumour growth in DLBCL [34]. Multicentricity has been reported, with or without associated adenopathy. In the throat, at the base of the tongue, where tongue cancer may develop with few signs and symptoms (hypopharyngeal tongue cancer). Primary non-Hodgkin lymphoma of the tongue base: the clinicopathology of seven cases and evaluation of HPV and EBV status. Mohd Ridah LJ, A Talib N, Muhammad N, Hussain FA, Zainuddin N. p16 Tumor Suppressor Gene Methylation in Diffuse Large B Cell Lymphoma: A Study of 88 Cases at Two Hospitals in the East Coast of Malaysia. Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other abusable medications. Call your doctor or 911 if you think you may have a medical emergency. Non-Hodgkins lymphoma (NHL) primarily derived from the base of the tongue, is rare. The data used and/or analysed during the current study are available from the corresponding author on reasonable request. 2006;45:25871. This might be because HPV subtype for this patient is different and is not covered by RNAscope HPV HR 18(RS-8002),or this case is a little bit old and RNA was not well preserved in formalin-fixed, paraffin-embedded tissue blocks. Fluorescence in situ hybridization (FISH) analysis using Break Apart FISH Probes was used to detect BCL2, BCL6 and cMYC gene rearrangements. Cyclophosphamide, doxorubicin, vincristine, prednisone, Peripheral T cell lymphoma, not otherwise specified. TIA, SOX10 was obtained from Beijing XiYaJinQiao Biological Technology Co. Ltd. China. Neville BW, Damm DD, Allen CM, Chi AC. In contrast, they did not express CD3, CD10, CD23, or TdT. Must be distinguished from monomorphous T cell lymphoma. Article government site. Xinyu Ren and Yin Cheng contributed equally to this work. 2014;118:33847. Imaging and pathological findings of PTCL (case 3). Of the 6 B-cell NHL cases, 5 were DLBCLs and 1 was MCL. 1, pp. Lymphoid hyperplasia is a rapid increase in the number of normal cells (called lymphocytes) that are contained in lymph nodes. There is usually a bilateral . Four were staged at III and IV and had higher IPI scores (2 or 3). Although it had been described in the literature, occurrence within oral cavity is rare. Viral infections, such as HIV or hepatitis C virus (HCV), can also develop in immunocompromised patients. Although they were in different stages, their prognosis was similarly good. Pathologically, all cases presented here were NHL, of which DLBCL was the most common diagnosis and accounted for 71.4% of the patients. To the best of our knowledge, four cases have been reported, including our case and three cases from literature (Table 5) [17, 27, 40]. CAS Clinicopathological information including age, gender, tumour location, histological subtype, grading, staging, survival, and response to treatment was acquired from the archives. Pathology may also show indistinct germinal centres leading to erroneous diagnosis of follicular lymphoma [3]. Head and neck extranodal lymphoma in a single institute: a 17-year retrospective analysis. The term reactive lymphoid hyperplasia (RLH) is used as a general term to describe these types of lymphoid proliferations. Surgical debulking/excision is the treatment of choice. All cases were reviewed and diagnoses were confirmed based on basic morphology, immunohistochemistry staining, and rearrangement. Curr Top Microbiol Immunol. Pathol Res Pract. Cases of DLBCL, NOS were further divided based on immunohistochemistry into two subtypes, GC and NGC. The complaints due to severe HBT were noisy respiration, hoarseness, throat clearing, dry cough, globus pharyngeus, and nasal voice. https://doi.org/10.1182/blood-2003-05-1545. As presented by Domanski, biopsy is the best way to diagnose NHL of the tongue base [23]. For T cell receptor rearrangement, the IdentiClone TCRB, TCRG, and TCRD Gene Clonality Assays were used with gel detection (InVivoScribe Technologies, San Diego, CA, USA). Diagn Pathol 15, 30 (2020). 1, pp. MeSH Paracortical hyperplasia may be accompanied by vascular proliferation. Lopez-Guillermo A, Colomo L, Jimenez M, Bosch F, Villamor N, Arenillas L, Muntanola A, Montoto S, Gine E, Colomer D, Bea S, Campo E, Montserrat E. Diffuse large B-cell lymphoma: clinical and biological characterization and outcome according to the nodal or extranodal primary origin. EBV ISH was performed using EBV-encoded Small RNA (EBER) probes (Bond ready-to-use ISH, Catalogue No: PB0589, Leica Biosystems Newcastle, Ltd.) according to the manufacturers protocol. Dr. Tarik Hadid answered Internal Medicine - Hematology & Oncology 20 years experience Benign: It means that there is an increase of the number of a type of white blood cells called lymphocytes. Peripheral T-cell lymphoma mimicking marginal zone B-cell lymphoma. https://doi.org/10.1016/j.oooo.2014.06.002. van der Waal RI, Huijgens PC, van der Valk P, van der Waal I. Characteristics of 40 primary extranodal non-Hodgkin lymphomas of the oral cavity in perspective of the new WHO classification and the international prognostic index. For DNA detection of high-riskin situ HPV infection, biotin-labelled HPV probe solutions (Leica, Newcastle, UK) were added to formalin-fixed, paraffin-embedded tissue sections. 2002;15:4205. 37, no. St. Louis, MO: Elsevier; 2017. The lingual tonsils are aggregations of lymphoid follicles that mediate B- and T-cell lymphocytes, which serve a role in formulating the immune system. Provided by the Springer Nature SharedIt content-sharing initiative. Harabuchi Y, Tsubota H, Ohguro S, Himi T, Asakura K, Kataura A, Ohuchi A, Hareyama M. Prognostic factors and treatment outcome in non-Hodgkin's lymphoma of Waldeyer's ring. Polyclonal lymphoid proliferation with immunohistochemistry stains for kappa or lambda light chains are diagnostic. By using this website, you agree to our MeSH Carcinomas of the base of the tongue: diagnosis using double-contrast radiography of the pharynx. Cancer that develops in the base of the tongue is a type of head and neck cancer. As both peripheral T cell lymphoma and MCL are extremely rare in the tongue base, we would like to describe these two cases in detail as follows. Authors M Gromet , M J Homer , B L Carter PMID: 7111732 DOI: 10.1148/radiology.144.4.7111732 No abstract available Publication types Case Reports MeSH terms Adult Barium Sulfate Deglutition Diagnosis, Differential Female The biopsy showed recurrence, with bone marrow involvement. Article c. Tumour cell infiltrated squamous epithelium (400x). Google Scholar. Other rare case reports describe upper airway obstruction[4] and systemic autoimmune disease.[5]. This site needs JavaScript to work properly. California Privacy Statement, Morphologically, LH is identified by dense lymphoid hyperplasia within the lamina propria and submucosa, replacing mucous glands. An abstract is unavailable. In our case, the late stage of disease, the morphologically blastic variant [44], and involvement of neck lymph nodes were all factors that contributed to poor prognosis of this patient. 1987;149:57581. I understand that this is benign, but what could be the cause? Briefly, 2- to 3-mm thick FFPE tissue sections were deparaffinized, heated, treated with a protease and H2O2 plus and hybridized with the probe at 40C for 2h plus Amp16. CD30 antibodies were purchased from Maixin Biotech. Lymphoid hyperplasia is not a disease or a tumor, but simply a term we use to represent enlarged tissue masses. 1979 Sep;30(5):485-8. doi: 10.1016/s0009-9260(79)80176-2. 4, pp. Accessibility Would you like email updates of new search results? Dr. Burkhart was awarded an affiliate fellow status in the American Academy of Oral Medicine in 2016. Depending upon the location of the RLH, the appearance of tissue may vary. Globus pharyngeus: a review of etiology, diagnostics, and treatment. LH most commonly affects older patients, with a mean age of 61 and female-to-male ratio of nearly 3:1. When on the surface tissue, there may be a yellow, white, or even vesicular appearance, as seen in Figure 1. As shown in Table1, all primary lesion locations were considered at the base of the tongue. Unauthorized use of these marks is strictly prohibited. [2], Follicular hyperplasia is a stimulation of the B cell compartment. A case of benign. Nancy W. Burkhart, EdD, BSDH, AFAAOM, is an adjunct associate professor in the Department of Periodontics-Stomatology, College of Dentistry, Texas A&M University, Dallas, Texas. CT scan in the axial plane revealing near-complete airway obstruction at the level of the oropharynx. Article PubMed Central When we think of lymphoid hyperplasia in the oral cavity, we often think of localized increases of lymph node tissue. External beam radiation has been successful in a single case [6]. A mass was identified in the right base of the tongue that caused breathing difficulties. Benign Lymphoid Hyperplasia of the Tongue Base Causing Upper Airway Obstruction Severe benign lymphoid hyperplasia (LH) is unusual in the head and neck region, but the diagnosis of LH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and pathologically. Cytoplasmic composition also varied between cases, from abundant to scant. Zhiyong Liang or Beverly Wang. 1991;6(3):170-8. doi: 10.1007/BF02493520. There were no c-Myc rearrangements, so there were no double or triple hit B cell lymphomas in these cases (Table3). Clipboard, Search History, and several other advanced features are temporarily unavailable. Sirsath NT, Lakshmaiah KC, Das U, Lokanatha D, Chennagiri SP, Ramarao C. Primary extranodal non-Hodgkin's lymphoma of oral cavity--a single Centre retrospective study. 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