Some people describe the pain as an intense burning sensation. The most common complication of shingles is long-term nerve pain called postherpetic neuralgia (PHN). Shingrix is also recommended for adults 19 years and older who have weakened immune systems because of disease or therapy. For most people, the second dose should be given 2 to 6 months after the first dose. Harpaz R, Ortega-Sanchez IR, Seward JF. Most often these components are whole viruses or bacteria, parts of the viruses or bacteria, or products made by bacteria, called toxins. The CDC recommends adults ages 50 and older and immunocompromised adults ages 19 and over get two doses of Shingrix. NEJM. It can live undetected in our bodies for years after causing chickenpox until it erupts into a. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. Some people who have or will have a weakened immune system can get the second dose 1 to 2 months after the first dose. Common Shingrix side effects include: headache, muscle pain; feeling tired; stomach pain, nausea, vomiting, diarrhea; fever, shivering; or. About 1 out of 10 adults who received Shingrix reported grade 3 injection-site symptoms such as pain, redness, and swelling. ", ProCon.org. Shingrix Ingredients . They help us to know which pages are the most and least popular and see how visitors move around the site. In a clinical trial of more than 30,000 participants, vaccine efficacy was 96.6% in adults aged 50 to 59 years, 97.4% in adults aged 60 to 69 years, and 91.3% in adults aged 70 years and older. Centers for Disease Control and Prevention. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Reporting is encouraged for any clinically significant adverse event even if it is uncertain whether the vaccine caused the event. Most side effects are mild to moderate, and last 1-3 days. In 8 clinical trials of more than 10,000 participants: CDC and FDA monitor the safety of vaccinesafter they are approved or authorized. Tell your vaccination provider if the person getting the vaccine: In some cases, your health care provider may decide to postpone shingles vaccination until a future visit. SHINGRIX is a vaccine indicated for prevention of herpes zoster (HZ) (shingles): in adults aged 50 years and older. A 2013 study showed that patients with a history of a previous shingles rash had the same side effects after Zostavax as those with no history of shingles. The shingles vaccine does not contain thimerosal (a preservative containing mercury). Either administer it immediately, or store it in the refrigerator and use it within 6 hours of reconstitution. The FDA adds that individuals older than 18 at a higher risk of shingles are also eligible for the vaccine. The efficacy of two doses of Shingrix for the prevention of postherpetic neuralgia (PHN) was high: 91.2% in adults aged 50 years and older, and 88.8% in adults aged 70 years and older. Even if you have side effects from the first dose, it is important to get the second dose to build strong protection against shingles. Consider delaying vaccination if your patient is pregnant, lactating, or experiencing an acute episode of shingles. Since the risk of herpes zoster increases with age, providers should weigh a patients risk of herpes zoster with the age-specific protection expected from Zostavax to determine when to vaccinate with Shingrix. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. Your health care provider can give you more information. About 1 out of 10 reported grade 3 systemic reactions such as myalgia (muscle pain), fatigue (feeling tired), headache, shivering, fever, and gastrointestinal illness. Healthcare providers and vaccine manufacturers are required by law to report certain adverse events following vaccination to VAERS; patients and caregivers can also submit reports. Many people have redness and swelling on their arm spanning several inches where they got the shot. Symptoms usually go away on their own in 2 to 3 days. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. Schmader KE, Levin MJ, Gnann JW Jr, McNeil SA, Vesikari T, et al. Manufacturer: Wyeth Pharmaceuticals, Inc. E. coli, fermentation growth media, polysorbate 80 (PS80), polysorbate 80, Al+ as AlPO4, histidine buffered saline, Meningococcal Polysaccharide Vaccine, Groups A, C, Y and W-135 Combined, Menomune-A/C/Y/W-135 Package Insert (Mar. Symptoms of a severe allergic reaction can include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, and weakness. NEJM. Shingles Vaccine Ingredients Shingrix is a recombinant vaccine. Fenton medium containing a bovine extract, Latham medium derived from bovine casein, formaldehyde, Stainer-Scholte liquid medium, glutaraldehyde, aluminum hydroxide, VERO cells, calf serum and lactalbumin hydrolysate, filamentous hemagglutinin (FHA), pertactin (69 kiloDalton outer membrane protein), aluminum hydroxide, sodium chloride, formaldehyde, polysorbate 80 (Tween 80), neomycin sulfate, polymyxin B, Quadracel version 1 Package Insert (Feb, 2021), Quadracel version 2 Package Insert (Dec. 2019), version 1: Muellers growth medium, ammonium sulfate, formaldehyde, Mueller-Miller casamino acid medium without beef heart infusion, aluminum phosphate, Stainer-Scholte medium, casamino acids, dimethyl-betacyclodextrin, glutaraldehyde, aluminum phosphate, MRC-5 cells, CMRL (Connaught Medical Research Laboratories) 1969 medium supplemented with calf serum, Medium 199 without calf serum, 2-phenoxyethanol, water, version 2: Muellers growth medium, ammonium sulfate, formaldehyde, Mueller-Miller casamino acid medium without beef heart infusion, aluminum phosphate, Stainer-Scholte medium, casamino acids, dimethyl-betacyclodextrin, glutaraldehyde, Vero cells, Iscoves medium, calf serum, M199 medium without calf serum, 2-phenoxyethanol, water, version 1: filamentous hemagglutinin(FHA), pertactin (PRN), fimbriae types 2 and 3 (FIM), aluminum phosphate, 2-phenoxyethanol, water, polysorbate 80, formaldehyde, glutaraldehyde, bovine serum albumin, 2-phenoxyethanol, neomycin, polymyxin B sulfate, version 2: filamentous hemagglutinin (FHA), pertactin (PRN), fimbriae types 2 and 3 (FIM), aluminum phosphate, polysorbate 80, 2-phenoxyethanol, formaldehyde, glutaraldehyde, bovine serum albumin, streptomycin sulphate, neomycin and polymyxin B sulphate, 11. Also, you are more likely to have severe, long-term pain if you get shingles when you are older. Shingrix provides stronger protection against shingles compared to Zostavax. All information these cookies collect is aggregated and therefore anonymous. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. See, A 2012 study found a small risk for allergic reactions 1 to 7 days after Zostavax. Safety and tolerability of zoster vaccine in adults 60 years old. Vaccines for preventing herpes zoster in older adults. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. About 1 out of 6 people had symptoms severe enough to prevent them from doing regular activities. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. Getting vaccinated is the best way to prevent shingles. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. 33. loss of bladder or bowel control. Clin Infect Dis. Safety of Zoster Vaccine in Elderly Adults Following Documented Herpes Zoster. Common Ingredients: Medical Research Council 5, human diploid cells (cells containing two sets of chromosomes) derived from the normal lung tissues of a 14-week-old male fetus aborted for "psychiatric reasons" in 1966 in the United Kingdom, Eagle's Basal Medium in Earle's balanced salt solution with bovine serum. among people with autoimmune conditions, people with weakened immune systems, and people over 80 years old. Shingles (also called herpes zoster) is the disease caused when the chickenpox virus reactivates. Recombinant shingles vaccine is recommended for: Shingles vaccine is given as a two-dose series. It also causes chickenpox. Macmorine, Improved Chemically Defined Basal Medium (CMRL-1969) for Primary Monkey Kidney and Human Diploid Cells, Applied and Environmental Microbiology, aem.asm.org, 1971, International Serum Industry Association, FAQ, serumindustry.org/faq, 2013, Pontifical Academy for Life, Moral Reflections on Vaccines Prepared from Cells Derived from Aborted Human Foetuses, immunize.org/concerns/vaticandocument.htm, June 9, 2005, Rebecca Sheets, History and Characterization of the Vero Cell Line, da.gov, May 12, 2000, Sigma-Aldrich, DMEM, sigmaaldrich.com, 2013. You will be subject to the destination website's privacy policy when you follow the link. Inactivating (germ-killing) ingredients , like formaldehyde, to weaken or kill viruses, bacteria, or toxins in the vaccine. About 1 in 4 people have a . Here are the proper bibliographic citations for this page according to four style manuals (in alphabetical order): [Editor's Note: The APA citation style requires double spacing within entries. These side effects may temporarily prevent a vaccinated person from doing regular activities. However, there are no data or theoretical concerns to indicate that Shingrix would be less safe or less effective when given at an interval shorter than 5 years following Zostavax. 2021), ProQuad Refrigerated Package Insert (Oct. 2018), Refrigerator-Stable Formulation: chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, Frozen Formulation Recombinant Human Albumin (RHA): embryo cell culture; WI-38 human diploid lung fibroblasts, MRC-5 cells, Frozen Formulation Human SerumAlbumin (HSA): chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, Frozen: chick embryo cell culture, WI-38 human diploid lung, MRC-5 cells, Refrigerated: chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, Refrigerator-Stable Formulation: sucrose, hydrolyzed gelatin, urea, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate, recombinant human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components of MRC-5 cells including DNA and protein, neomycin, bovine serum albumin, other buffer and media ingredients, Frozen Formulation Recombinant Human Albumin (RHA): sucrose, hydrolyzed gelatin, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate dibasic, recombinant human albumin, sodium bicarbonate, potassium phosphate monobasic, potassium chloride; potassium phosphate dibasic, residual components of MRC-5 cells including DNA and protein, neomycin, bovine calf serum, other buffer and media ingredients, Frozen Formulation Human SerumAlbumin (HSA): sucrose, hydrolyzed gelatin, urea, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate, recombinant human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components of MRC-5 cells including DNA and protein, neomycin, bovine serum albumin, other buffer and media ingredients, Frozen: sucrose, hydrolyzed gelatin, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate dibasic, recombinant human albumin, sodium bicarbonate, potassium phosphate monobasic, potassium chloride, potassium phosphate dibasic, residual components from the manufacturing process [MRC-5 cells including DNA and protein, neomycin, bovine calf serum, other buffer and media ingredients], Refrigerated: sucrose, sorbitol, hydrolyzed gelatin, urea, sodium chloride, sodium phosphate, monosodium L-glutamate, recombinant human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components from the manufacturing process [MRC-5 cells including DNA and protein, neomycin, bovine calf serum, other buffer and media ingredients], Meningococcal (Groups A, C, Y, and W-135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine, Manufacturer: GlaxoSmithKline Biologicals SA, Franz Complete medium, formaldehyde, CY medium [yeast extracts, amino acids], Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine, Mueller Hinton agar, Watson Scherp media [casamino acid], modified culture medium [hydrolyzed casein], formaldehyde, ammonium sulfate, sodium phosphate buffered isotonic sodium chloride solution, formaldehyde, Manufacturer: Novartis Vaccines and Diagnostics, Inc, Escherichia coli, deoxycholate, aluminum hydroxide, Neisserial adhesin A (NadA), Neisserial Heparin Binding Antigen (NHBA), factor H binding protein (fHbp), outer membrane vesicles (OMV), aluminum hydroxide, sodium chloride, histidine, sucrose, kanamycin. Safety, tolerability, and immunogenicity of zoster vaccine in subjects with a history of herpes zoster. All information these cookies collect is aggregated and therefore anonymous. They help us to know which pages are the most and least popular and see how visitors move around the site. MMR & Varicella (measles, mumps, rubella, & chickenpox), 33. Side effects usually go away after 2 to 3 days. By preventing shingles, recombinant shingles vaccine also protects against PHN and other complications. Shingles is a viral infection caused by herpes zoster, the same virus responsible for chickenpox. Vaccine recipients may take over-the-counter pain medicine like ibuprofen or acetaminophen to ease discomfort from these side effects. Vaccines, like any medicine, can have side effects. Get CDCs official recommended immunization schedules for children, adolescents, and adults. Manufacturer: Emergent BioDefense Operations Lansing LLC, amino acids, vitamins, inorganic salts, sugars, proteins [including the 83kDa protective antigen (PA) protein], aluminum, benzethonium chloride, formaldehyde, glycerin, asparagine, citric acid, potassium phosphate, magnesium sulfate, iron ammonium citrate. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. MMWR. Safety, tolerability, and immunogenicity after 1 and 2 doses of zoster vaccine in healthy adults 60 years of age. Stainer-Scholte medium, casamino acids, dimethyl-beta-cyclodextrin, glutaraldehyde, formaldehyde, aluminum phosphate, Muellers growth medium, ammonium sulfate, Mueller-Miller casamino acid medium (without beef heart infusion), 2-phenoxyethanol, water, filamentous hemagglutinin (FHA), pertactin (PRN), fimbriae types 2 and 3 (FIM), aluminum phosphate, formaldehyde, glutaraldehyde, 2-phenoxyethanol, 9. 2012 Jan 20;30(5):904-10. These can include cool. For more information, see Report an Adverse Event to VAERS. Pregnant women, some people who have medical conditions or are taking medications that could weaken the immune system (ask your doctor if you have concerns), and people with a history of severe allergic reaction (e.g., anaphylaxis) to any component of the vaccine. 325 N. LaSalle Street, Suite 200 Proper citation depends on your preferred or required style manual. Recombinant Zoster Vaccine (2/4/22), Department of Health and Human Services You can protect yourself against shingles. Accessed February 21, 2023. https://vaccines.procon.org/vaccine-ingredients-and-manufacturer-information/, Born Gay? The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Recombinant zoster (shingles) vaccine can prevent shingles. In addition to the rash, shingles can cause fever, headache, chills, or upset stomach. You should tell patients to expect such reactions as pain, swelling, and redness . So its very important that you get this vaccine. Influenza A (H1N1) Vaccine(swine flu), Influenza A (H1N1) 2009 Monovalent Vaccine, allantoic fluid of embryonated chicken eggs, sucrose density gradient, betapropiolactone, sodium taurodeoxycholate, phosphate buffered isotonic solution, thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, neomycin sulfate, polymyxin B, beta-propiolactone, pathogen-free (SPF) eggs, stabilizing buffer, monosodium glutamate, hydrolyzed porcine gelatin, arginine, sucrose, dibasic potassium phosphate, monobasic potassium phosphate, gentamicin sulfate, Manufacturer: ID Biomedical Corporation of Quebec, allantoic cavity of embryonated hens eggs, formaldehyde, sodium deoxycholate, phosphate-buffered saline solution, thimerosal, egg proteins, formaldehyde, sodium deoxycholate, Manufacturer: Novartis Vaccines and Diagnostics Limited, allantoic cavity of embryonated hens eggs, neomycin, polymyxin, betapropiolactone, nonylphenol ethoxylate, phosphate buffered saline, thimerosal, egg proteins, polymyxin, neomycin, betapropiolactone, nonylphenol ethoxylate, embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, non-ionic surfactant, polyethylene glycol p-isooctylphenyl ether (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, polyethylene glycol p-isooctylphenyl ether, sucrose, thimerosal, Influenza Virus Vaccine, H5N1 (for National Stockpile), embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, nonionic surfactant, polyethylene glycol p-isooctylphenyl ether (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, porcine gelatin, thimerosal, formaldehyde, polyethylene glycol pIsooctylphenyl ether, sucrose, Influenza A (H5N1) Virus Monovalent Vaccine, Adjuvanted, phosphate-buffered saline solution, allantoic cavity of embryonated hens eggs, formaldehyde, sodium deoxycholate, squalene, DL--tocopherol, polysorbate 80, AS03 adjuvant emulsion, thimerosal, DL--tocopherol, polysorbate 80, ovalbumin, formaldehyde, sodium deoxycholate, Influenza A (H5N1) Monovalent Vaccine, Adjuvanted, Madin Darby Canine Kidney (MDCK) cells, culture medium, -propiolactone, cetyltrimethylammonium bromide, MF59C.1 adjuvant (MF59) [squalene, polysorbate 80, sorbitan trioleate, sodium citrate dihydrate, citric acid monohydrate] , protein other than HA, MDCK cell protein, MDCK cell DNA, polysorbate 80, cetyltrimethylammonium bromide, -propiolactone, thimerosal, Fluad Quadrivalent Package Insert (Mar. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. In rare cases, people who got vaccinated with Zostavax experienced a blister-like rash; some were found to have been caused by the vaccine. For other signs that concern you, call your health care provider. The Centers for Disease Control and Prevention (CDC) recommends that older and immunocompromised adults get two doses of Shingrix (the recombinant zoster vaccine, or RZV) to prevent shingles and related complications. Most people (78%) who got Shingrix reported at least some pain at the injection site. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Efficacy of the herpes zoster subunit vaccine in adults 70 years of age or older. DTaP-IPV-Hib Vaccine(diphtheria, tetanus, pertussis, polio, & haemophilus influenzae type B), Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjugate) Vaccine, Pentacel version 1 Package Insert (Feb. 2021), Pentacel version 2 Package Insert (Dec. 2019), version 1: Muellers growth medium, ammonium sulfate, formaldehyde, Mueller-Miller casamino acid medium without beef heart infusion, aluminum phosphate, Stainer-Scholte medium, casamino acids, dimethyl-betacyclodextrin, glutaraldehyde, aluminum phosphate, MRC-5 cells,, CMRL (Connaught Medical Research Laboratories) 1969 medium (supplemented with calf serum), Medium 199 (without calf serum), 2-phenoxyethanol, water, semi-synthetic medium, version 2: Muellers growth medium, ammonium sulfate, formaldehyde, Mueller-Miller casamino acid medium without beef heart infusion, aluminum phosphate, Stainer-Scholte medium, casamino acids, dimethyl-beta310 cyclodextrin, glutaraldehyde, Vero cells, Iscoves medium (supplemented with calf serum), M199 medium without calf serum, 2-phenoxyethanol, water, version 1: filamentous hemagglutinin (FHA), pertactin (PRN), fimbriae types 2 and 3 (FIM), aluminum phosphate, polysorbate 80, sucrose, formaldehyde, glutaraldehyde, bovine serum albumin, 2-phenoxyethanol, neomycin, polymyxin B sulfate. Shingles vaccination is the only way to protect against shingles and postherpetic neuralgia (PHN), the most common complication from shingles. L-histidine, polysorbate 20, sodium chloride, aluminum phosphate, soy peptone broth, casamino acids and yeast extract-based medium, chemically defined medium, polysorbate 80, succinate buffer, sodium chloride, aluminum phosphate, Poliovirus Vaccine Inactivated (Monkey Kidney Cell), Vero cells, Eagle MEM modified medium, newborn calf bovine serum, M-199 [without calf bovine serum], formalin, M-199 medium, 2-phenoxyethanol, formaldehyde, neomycin, streptomycin, polymyxin B, calf bovine serum albumin, human diploid cells [MRC-5 strain], beta-propiolactone, human albumin, neomycin sulfate, phenol red indicator, beta-propiolactone, Manufacturer: Novartis Vaccines and Diagnostics, chicken fibroblasts, synthetic cell culture medium [with added human albumin, polygeline (processed bovine gelatin), antibiotics], -propiolactone, sucrose density gradient, stabilizer solution [buffered polygeline, potassium glutamate], polygeline (processed bovine gelatin), human serum albumin, potassium glutamate, sodium EDTA, bovine serum, chicken protein, ovalbumin, neomycin, chlortetracycline, amphotericin B, amino acids, dextran, Dulbeccos Modified Eagle Medium (DMEM) [sodium chloride, potassium chloride, magnesium sulfate, ferric (III) nitrate, sodium phosphate, sodium pyruvate, D-glucose, concentrated vitamin solution, L-cystine, L-tyrosine, amino acids solution, Lglutamine, calcium chloride, sodium hydrogenocarbonate, phenol red], sorbitol, sucrose, Porcine circovirus type 1 (PCV-1), liquid diluent [calcium carbonate, sterile water, xanthan, calcium carbonate], Rotavirus Vaccine, Live, Oral, Pentavalent, sucrose, sodium citrate, sodium phosphate monobasic monohydrate, sodium hydroxide, polysorbate 80, cell culture media, fetal bovine serum, Smallpox and Mpox/Monkeypox Vaccine, Live, Non-Replicating, chicken embryo fibroblast (CEF) cells, serum-free medium, Tris (tromethamine), sodium chloride, host-cell DNA, protein, benzonase, gentamicin, ciprofloxacin. Centers for Disease Control and Prevention. Cochrane Database Syst Rev. Thank you for taking the time to confirm your preferences. Afluria Quadrivalent: thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, Afluria Quadrivalent Southern Hemisphere: thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, Flucelvax Quadrivalent Package Insert (Mar. To Zostavax see how visitors move around the site for allergic reactions 1 to 2 months after first. To 2 months after the first dose vaccine in adults 60 years age... 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